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You really shouldn't have to drill holes to get it to seat. Give both surfaces (base of the knot and the hole in the brush handle) a quick wipe with mineral spirits, let it dry, and you should be...

I use lock-tite marine epoxy (get it at lowes, Home Depot, etc) when I put brush knots in custom handles. Works great. Mix it, strengthens in 10 minutes, ready to use in 24 hours.