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What ever epoxy you have on hand will work. 5 min working time is usually long enough, use one with longer working time if you are not confident.

Jonathan

edit: well slow on the draw to day:)

Yes the interior diameter of the handle is the maximum size of knot that will fit. Usually you want a little difference between the knot diameter and the brush hole diameter. The depth of the recess...

Yes the bristles/knot can be replaced. There are many threads about doing this.

The bigger issue is do you know for certain what type of knot you want in your heirloom handle?

Jonathan