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You certainly can destroy an edge by overhoning on any stone. The coarser the stone the easier it is to overdo.

When you say alot of swipes how many is alot? I would go very easy on the 4K. It...

Well to answer some of your points; if the blade is unequally sharp your probably not applying equal pressure to the hone (actually you shouldn't add any pressure to it only the weight of the blade...