Yes I guess that I have noticed a bit of a difference in some. I have a couple of customs that were made with the tang a bit short and if the scales are too close it cramps my style a bit.

I like my scales to be nice and snug with the blade in the open (straight out) position. If they are not it will cause me to have to re-grip the razor in the midst of stropping. The width of the tang can be an issue as well. There is too thin, too thick and then there is just right. I haven't found one I can't adapt to though and get the job done.