Yes, a wrong choice of font for body text can be the difference between a pleasurable read and a bumpy ride on a road of letters. And sometimes its a question of choosing some font that stands up well to your media, like in the case of dailies (where I work) newsprint. A too fine or fancy font can get lost and become uncomfortable at the point sizes usually on body text (9.5 to 10.5) more or less, depending on the font.