That's generally true, but the big resources that can make irreversible difference tend to go with reason and caution. It's a bit like having nuclear weapons - you can do serious damage with them, but those with power to obliterate humankind have had more than enough sense not to go for it.

With regular type of big resources the damage one can inflict is probably comparable to something like a big industrial incident, say Exxon Valdez, or BP's Horizon, or Chernobil.