I've enjoyed some great vacations on East and West coasts and Florida, but not much in between. We have family in Canada so we have also travelled around BC (love the Rockies) and Ontario loads.

However, living in Europe makes it easy to visit very different cultures over very short distances. Spain, Germany, France, the Netherlands, Italy, Ireland, Portugal... all within a 2-hour flight but are very different experiences. For that reason alone I tend to favour travel in Europe.