Well, not to toot my own horn here, but check out the new UNO Flash game. You may have seen it on TV (read: been beaten over the head by it over and over until you cried out for mercy or bought it). If you're a serious strategy gamer who hates UNO because there's not enough decision making, you're never going to like UNO. But if you like something that gets you frantic and laughing out loud, flash was designed for you. It's the most fun I've had playing UNO.
I recommend booze (disclaimer: the company certainly does not advocate that).