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Absolutely, Experimentation is big part of this hobby. I've used a c12k slurry stone on my Escher or Thuringian in lieu of an Escher slurry stone with great results....

I too use a "well worn" dmt 325 for creating slurry from time to time. I use it all the time on my synthetics, very sparingly, a few figure 8's, helps create cutting slurry, and helps keep the stone...